Target name

P34998: Corticotropin-releasing factor receptor 1


  Protein function

G-protein coupled receptor for CRH (corticotropin-releasing factor) and UCN (urocortin). Has high affinity for CRH and UCN. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and down-stream effectors, such as adenylate cyclase. Promotes the activation of adenylate cyclase, leading to increased intracellular cAMP levels. Inhibits the activity of the calcium channel CACNA1H. Required for normal embryonic development of the adrenal gland and for normal hormonal responses to stress. Plays a role in the response to anxiogenic stimuli.

  Database links

Uniprot primary ID P34998
PDB ID 2L27 3EHS 3EHT 3EHU 4K5Y
DrugBank ID
BioGrid ID 107784
GuidetoPHARMACOLOGY ID 212
PharmGKB ID PA26874
KEGG ID hsa:1394;hsa:104909134
BioCyc
Entrez Gene (Gene ID) 104909134;1394
DIP
STRING 9606ENSP00000381333
MINT MINT-1217325
IntAct P34998
DMDM 461836
BREDNA
Rectome R-HSA-373080 R-HSA-418555
SignaLink
BindingDB P34998

  Model Performance Metrics

Fingerprint type F1_CV AUC_CV Accuracy_CV Sensitivity_CV Specificity_CV F1_test AUC_test Accuracy_test Sensitivity_test Specificity_test Download model
FP2 fingerprints 0.902 0.931 0.902 0.909 0.895 0.893 0.927 0.893 0.922 0.865 Download
MACCS fingerprints 0.871 0.939 0.868 0.887 0.850 0.879 0.950 0.873 0.897 0.848 Download
Daylight fingerprints 0.769 0.778 0.769 0.772 0.766 0.769 0.782 0.771 0.782 0.760 Download
ECFP2 fingerprints 0.943 0.982 0.945 0.916 0.974 0.955 0.987 0.957 0.941 0.972 Download
ECFP4 fingerprints 0.964 0.982 0.965 0.941 0.989 0.980 0.989 0.981 0.966 0.995 Download
ECFP6 fingerprints 0.961 0.979 0.962 0.934 0.990 0.981 0.987 0.982 0.968 0.995 Download

  Download datasets

Positive dataset Negative dataset


Copyright @ 2012-2014 Computational Biology & Drug Design Group,
School of Pharmaceutical Sciences, Central South University. All rights reserved.

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