Details-Calcnet-AlzheimerNet

Target name

Q07343: cAMP-specific 3',5'-cyclic phosphodiesterase 4B

Protein function

Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. May be involved in mediating central nervous system effects of therapeutic agents ranging from antidepressants to antiasthmatic and anti-inflammatory agents.

Database links

Uniprot primary ID	Q07343
PDB ID	1RO6 3HC8 4NW7 1RO9 3O57 3O56 3O0J 1XLZ 1XLX 3KKT 2QYL 1TB5 4X0F 3GWT 3D3P 1XM4 3HDZ 3LY2 1XM6 1Y2H 1Y2J 4KP6 1XMU 1XMY 1XOT 3W5E 1XOS 1F0J 1JP1 1JP2 3HMV 4MYQ 2CHM 3FRG 1ROR 3WD9 1XN0 3G45 4WZI
DrugBank ID	DB00131 DB01088 DB01427 DB00651 DB00920 DB01113 DB05266 DB01656 DB00201 DB00824 DB01412 DB00806 DB00277
BioGrid ID	111168
GuidetoPHARMACOLOGY ID	1301
PharmGKB ID	PA33129
KEGG ID	hsa:5142
BioCyc
Entrez Gene (Gene ID)	5142
DIP
STRING	9606ENSP00000332116
MINT
IntAct	Q07343
DMDM	729163
BREDNA	31453
Rectome	R-HSA-180024 R-HSA-418555
SignaLink
BindingDB	Q07343

Model Performance Metrics

Fingerprint type	F1_CV	AUC_CV	Accuracy_CV	Sensitivity_CV	Specificity_CV	F1_test	AUC_test	Accuracy_test	Sensitivity_test	Specificity_test	Download model
FP2 fingerprints	0.780	0.853	0.791	0.729	0.856	0.814	0.906	0.832	0.753	0.907	Download
MACCS fingerprints	0.714	0.773	0.705	0.727	0.682	0.779	0.845	0.771	0.825	0.720	Download
Daylight fingerprints	0.757	0.754	0.745	0.782	0.708	0.756	0.763	0.763	0.753	0.772	Download
ECFP2 fingerprints	0.862	0.928	0.859	0.870	0.848	0.891	0.956	0.892	0.903	0.883	Download
ECFP4 fingerprints	0.918	0.959	0.918	0.906	0.931	0.914	0.976	0.918	0.896	0.938	Download
ECFP6 fingerprints	0.901	0.953	0.905	0.856	0.955	0.911	0.967	0.918	0.864	0.969	Download

Download datasets

Positive dataset

Negative dataset