AlzheimerNet
Models established using Daylight fingerprints
Details Uniprot_ID Protein F1_CV AUC_CV Accuracy_CV Sensitivity_CV Specificity_CV F1_test AUC_test Accuracy_test Sensitivity_test Specificity_test
View O00519 Fatty-acid amide hydrolase 1 0.715 0.730 0.706 0.740 0.672 0.748 0.771 0.736 0.772 0.700
View O14672 Disintegrin and metalloproteinase domain-containing protein 10 0.676 0.767 0.817 0.567 0.945 0.735 0.794 0.828 0.655 0.927
View O95263 High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B 0.959 0.964 0.960 0.921 1.000 0.974 0.975 0.984 0.950 1.000
View P00488 Coagulation factor XIII A chain 0.882 0.897 0.881 0.888 0.875 0.973 0.977 0.975 1.000 0.955
View P00491 Purine nucleoside phosphorylase 0.917 0.919 0.918 0.909 0.926 0.926 0.928 0.927 0.893 0.963
View P00519 Tyrosine-protein kinase ABL1 0.763 0.781 0.755 0.787 0.724 0.746 0.760 0.736 0.790 0.684
View P00747 Plasminogen 0.683 0.726 0.701 0.648 0.754 0.723 0.753 0.745 0.735 0.754
View P00749 Urokinase-type plasminogen activator 0.694 0.735 0.710 0.697 0.721 0.745 0.790 0.769 0.731 0.801
View P00750 Tissue-type plasminogen activator 0.642 0.671 0.642 0.728 0.573 0.716 0.734 0.675 0.889 0.492
View P00797 Renin 0.845 0.870 0.852 0.805 0.900 0.867 0.889 0.871 0.832 0.910
View P01275 Glucagon 0.966 0.967 0.967 0.933 1.000 0.977 0.977 0.981 0.955 1.000
View P01375 Tumor necrosis factor 0.593 0.674 0.671 0.481 0.859 0.610 0.676 0.662 0.510 0.825
View P02766 Transthyretin 0.661 0.691 0.667 0.643 0.691 0.667 0.649 0.643 0.667 0.615
View P03372 Estrogen receptor 0.764 0.810 0.766 0.760 0.772 0.799 0.848 0.794 0.808 0.780
View P03956 Interstitial collagenase 0.769 0.800 0.782 0.724 0.840 0.773 0.801 0.781 0.730 0.834
View P04035 3-hydroxy-3-methylglutaryl-coenzyme A reductase 0.817 0.838 0.832 0.747 0.918 0.824 0.821 0.802 0.764 0.861
View P04049 RAF proto-oncogene serine/threonine-protein kinase 0.787 0.833 0.816 0.674 0.960 0.782 0.823 0.822 0.675 0.953
View P04062 Glucosylceramidase 0.564 0.599 0.583 0.683 0.518 0.648 0.648 0.642 0.745 0.559
View P04156 Major prion protein 0.689 0.723 0.714 0.631 0.798 0.720 0.752 0.738 0.667 0.811
View P04439 HLA class I histocompatibility antigen, A-3 alpha chain 0.997 0.997 0.997 1.000 0.993 1.000 1.000 1.000 1.000 1.000
View P04626 Receptor tyrosine-protein kinase erbB-2 0.802 0.817 0.804 0.785 0.824 0.818 0.835 0.823 0.798 0.848
View P04629 High affinity nerve growth factor receptor 0.866 0.878 0.875 0.804 0.947 0.856 0.868 0.868 0.787 0.950
View P04798 Cytochrome P450 1A1 0.750 0.772 0.762 0.711 0.813 0.588 0.645 0.632 0.625 0.636
View P05067 Amyloid beta A4 protein 0.693 0.717 0.702 0.670 0.733 0.809 0.810 0.795 0.826 0.762
View P05091 Aldehyde dehydrogenase, mitochondrial 0.918 0.924 0.923 0.848 1.000 0.963 0.964 0.957 0.929 1.000
View P05093 Steroid 17-alpha-hydroxylase/17,20 lyase 0.799 0.816 0.801 0.792 0.811 0.802 0.813 0.809 0.786 0.831
View P05121 Plasminogen activator inhibitor 1 0.738 0.756 0.747 0.714 0.780 0.842 0.813 0.821 0.851 0.784
View P05164 Myeloperoxidase 0.765 0.771 0.771 0.740 0.803 0.889 0.902 0.897 0.941 0.864
View P05230 Fibroblast growth factor 1 0.793 0.823 0.798 0.774 0.823 0.828 0.838 0.839 0.800 0.875
View P05362 Intercellular adhesion molecule 1 0.752 0.795 0.792 0.632 0.953 0.793 0.848 0.811 0.670 0.976
View P06213 Insulin receptor 0.836 0.857 0.837 0.827 0.848 0.845 0.893 0.851 0.828 0.874
View P06239 Tyrosine-protein kinase Lck 0.792 0.788 0.777 0.851 0.702 0.819 0.816 0.798 0.911 0.684
View P06241 Tyrosine-protein kinase Fyn 0.680 0.681 0.674 0.695 0.653 0.760 0.769 0.750 0.760 0.739
View P06276 Cholinesterase 0.634 0.652 0.641 0.620 0.661 0.637 0.662 0.641 0.622 0.660
View P06493 Cyclin-dependent kinase 1 0.777 0.804 0.769 0.802 0.735 0.794 0.845 0.790 0.806 0.774
View P07339 Cathepsin D 0.829 0.842 0.830 0.821 0.839 0.830 0.848 0.842 0.823 0.858
View P07384 Calpain-1 catalytic subunit 0.820 0.838 0.827 0.783 0.871 0.881 0.892 0.879 0.894 0.865
View P07550 Beta-2 adrenergic receptor 0.853 0.870 0.859 0.813 0.906 0.842 0.865 0.850 0.817 0.881
View P07858 Cathepsin B 0.733 0.762 0.742 0.712 0.772 0.773 0.791 0.766 0.810 0.722
View P08069 Insulin-like growth factor 1 receptor 0.748 0.764 0.750 0.739 0.762 0.782 0.775 0.771 0.774 0.768
View P08172 Muscarinic acetylcholine receptor M2 0.721 0.726 0.708 0.763 0.654 0.737 0.724 0.712 0.789 0.631
View P08183 Multidrug resistance protein 1 0.642 0.724 0.673 0.585 0.761 0.737 0.821 0.755 0.715 0.791
View P08253 72 kDa type IV collagenase 0.793 0.834 0.805 0.744 0.868 0.825 0.856 0.832 0.787 0.877
View P08254 Stromelysin-1 0.822 0.867 0.834 0.765 0.904 0.856 0.877 0.857 0.816 0.902
View P08311 Cathepsin G 0.632 0.626 0.601 0.681 0.519 0.753 0.788 0.741 0.780 0.700
View P08473 Neprilysin 0.778 0.775 0.765 0.793 0.735 0.767 0.749 0.742 0.767 0.711
View P08908 5-hydroxytryptamine receptor 1A 0.758 0.823 0.775 0.702 0.849 0.770 0.833 0.785 0.716 0.854
View P08913 Alpha-2A adrenergic receptor 0.692 0.775 0.721 0.629 0.813 0.727 0.778 0.728 0.730 0.727
View P09874 Poly [ADP-ribose] polymerase 1 0.841 0.867 0.841 0.838 0.845 0.861 0.882 0.858 0.852 0.865
View P09917 Arachidonate 5-lipoxygenase 0.671 0.704 0.675 0.659 0.691 0.752 0.795 0.744 0.776 0.713
View P10275 Androgen receptor 0.728 0.796 0.759 0.643 0.875 0.735 0.810 0.763 0.652 0.875
View P10635 Cytochrome P450 2D6 0.640 0.682 0.661 0.694 0.636 0.635 0.661 0.656 0.683 0.636
View P11086 Phenylethanolamine N-methyltransferase 0.755 0.724 0.708 0.898 0.518 0.800 0.792 0.768 0.941 0.600
View P11229 Muscarinic acetylcholine receptor M1 0.718 0.728 0.706 0.757 0.655 0.761 0.760 0.748 0.804 0.693
View P11274 Breakpoint cluster region protein 0.830 0.854 0.843 0.761 0.927 0.881 0.889 0.880 0.839 0.927
View P11473 Vitamin D3 receptor 0.759 0.793 0.803 0.682 0.905 0.766 0.808 0.818 0.667 0.940
View P11511 Aromatase 0.619 0.648 0.636 0.587 0.686 0.663 0.687 0.676 0.638 0.714
View P12821 Angiotensin-converting enzyme 0.876 0.879 0.873 0.893 0.853 0.882 0.900 0.887 0.871 0.902
View P13569 Cystic fibrosis transmembrane conductance regulator 0.874 0.883 0.883 0.811 0.955 0.850 0.868 0.893 0.773 0.971
View P14174 Macrophage migration inhibitory factor 0.489 0.560 0.529 0.450 0.608 0.612 0.709 0.683 0.652 0.703
View P14324 Farnesyl pyrophosphate synthase 0.804 0.790 0.791 0.835 0.745 0.810 0.792 0.794 0.825 0.760
View P14555 Phospholipase A2, membrane associated 0.766 0.787 0.786 0.702 0.869 0.831 0.843 0.834 0.771 0.905
View P14780 Matrix metalloproteinase-9 0.821 0.847 0.830 0.777 0.883 0.856 0.884 0.860 0.825 0.895
View P15559 NAD(P)H dehydrogenase [quinone] 1 0.863 0.886 0.879 0.759 1.000 0.848 0.868 0.875 0.737 1.000
View P16050 Arachidonate 15-lipoxygenase 0.650 0.658 0.633 0.697 0.572 0.732 0.722 0.676 0.938 0.444
View P16083 Ribosyldihydronicotinamide dehydrogenase [quinone] 0.766 0.762 0.747 0.827 0.667 0.824 0.860 0.854 0.824 0.875
View P16109 P-selectin 0.557 0.613 0.574 0.708 0.492 0.550 0.640 0.625 0.688 0.594
View P17612 cAMP-dependent protein kinase catalytic subunit alpha 0.656 0.742 0.774 0.556 0.912 0.483 0.670 0.681 0.333 0.962
View P17787 Neuronal acetylcholine receptor subunit beta-2 0.709 0.716 0.713 0.698 0.727 0.714 0.705 0.708 0.734 0.682
View P18054 Arachidonate 12-lipoxygenase, 12S-type 0.563 0.599 0.595 0.573 0.614 0.500 0.607 0.607 0.571 0.625
View P19438 Tumor necrosis factor receptor superfamily member 1A 0.747 0.791 0.783 0.644 0.920 0.844 0.846 0.841 0.792 0.900
View P19525 Interferon-induced, double-stranded RNA-activated protein kinase 0.592 0.616 0.602 0.578 0.625 0.686 0.659 0.656 0.667 0.643
View P21397 Amine oxidase [flavin-containing] A 0.609 0.658 0.615 0.603 0.627 0.722 0.743 0.711 0.790 0.639
View P21728 D(1A) dopamine receptor 0.649 0.709 0.695 0.564 0.825 0.673 0.755 0.707 0.610 0.802
View P21730 C5a anaphylatoxin chemotactic receptor 1 0.818 0.836 0.829 0.765 0.894 0.780 0.801 0.797 0.716 0.879
View P21917 D(4) dopamine receptor 0.741 0.748 0.737 0.748 0.726 0.744 0.741 0.734 0.759 0.708
View P22102 Trifunctional purine biosynthetic protein adenosine-3 0.831 0.839 0.810 0.937 0.683 0.857 0.786 0.813 1.000 0.571
View P22303 Acetylcholinesterase 0.632 0.652 0.638 0.621 0.655 0.651 0.668 0.649 0.646 0.652
View P23219 Prostaglandin G/H synthase 1 0.505 0.614 0.598 0.596 0.599 0.526 0.632 0.615 0.641 0.602
View P23443 Ribosomal protein S6 kinase beta-1 0.890 0.900 0.899 0.813 0.987 0.911 0.917 0.914 0.847 0.988
View P24385 G1/S-specific cyclin-D1 0.764 0.766 0.751 0.794 0.707 0.757 0.783 0.765 0.740 0.789
View P25025 C-X-C chemokine receptor type 2 0.800 0.838 0.826 0.692 0.961 0.789 0.814 0.800 0.759 0.840
View P25098 Beta-adrenergic receptor kinase 1 0.653 0.717 0.715 0.532 0.902 0.733 0.752 0.742 0.647 0.857
View P27338 Amine oxidase [flavin-containing] B 0.629 0.662 0.648 0.606 0.689 0.637 0.684 0.668 0.612 0.719
View P27695 DNA-(apurinic or apyrimidinic site) lyase 0.607 0.734 0.680 0.830 0.616 0.696 0.744 0.689 1.000 0.517
View P27986 Phosphatidylinositol 3-kinase regulatory subunit alpha 0.879 0.889 0.878 0.887 0.868 0.906 0.906 0.896 0.935 0.849
View P28223 5-hydroxytryptamine receptor 2A 0.759 0.833 0.775 0.706 0.845 0.763 0.846 0.776 0.718 0.835
View P28335 5-hydroxytryptamine receptor 2C 0.760 0.829 0.776 0.705 0.848 0.757 0.829 0.774 0.699 0.850
View P28482 Mitogen-activated protein kinase 1 0.821 0.864 0.846 0.702 0.993 0.863 0.893 0.873 0.759 1.000
View P28845 Corticosteroid 11-beta-dehydrogenase isozyme 1 0.760 0.826 0.786 0.678 0.893 0.771 0.852 0.795 0.689 0.902
View P29274 Adenosine receptor A2a 0.793 0.802 0.793 0.792 0.793 0.775 0.790 0.779 0.757 0.801
View P29466 Caspase-1 0.841 0.854 0.853 0.791 0.913 0.839 0.866 0.855 0.793 0.912
View P29474 Nitric oxide synthase, endothelial 0.520 0.597 0.594 0.604 0.589 0.533 0.566 0.558 0.600 0.527
View P29475 Nitric oxide synthase, brain 0.676 0.662 0.659 0.705 0.611 0.655 0.646 0.638 0.679 0.595
View P30291 Wee1-like protein kinase 0.854 0.867 0.866 0.787 0.945 0.828 0.848 0.853 0.738 0.958
View P30556 Type-1 angiotensin II receptor 0.765 0.776 0.770 0.747 0.793 0.733 0.753 0.754 0.716 0.787
View P30926 Neuronal acetylcholine receptor subunit beta-4 0.738 0.723 0.702 0.842 0.561 0.828 0.892 0.828 0.750 0.923
View P31645 Sodium-dependent serotonin transporter 0.686 0.704 0.689 0.678 0.699 0.721 0.730 0.714 0.707 0.723
View P31749 RAC-alpha serine/threonine-protein kinase 0.772 0.782 0.769 0.787 0.751 0.797 0.810 0.795 0.828 0.763
View P32297 Neuronal acetylcholine receptor subunit alpha-3 0.721 0.726 0.717 0.730 0.705 0.760 0.843 0.803 0.760 0.833
View P34972 Cannabinoid receptor 2 0.671 0.681 0.663 0.684 0.642 0.659 0.666 0.645 0.679 0.611
View P34998 Corticotropin-releasing factor receptor 1 0.769 0.778 0.769 0.772 0.766 0.769 0.782 0.771 0.782 0.760
View P35228 Nitric oxide synthase, inducible 0.666 0.678 0.670 0.654 0.686 0.638 0.681 0.655 0.597 0.714
View P35354 Prostaglandin G/H synthase 2 0.699 0.741 0.719 0.647 0.793 0.725 0.763 0.741 0.684 0.798
View P35462 D(3) dopamine receptor 0.745 0.755 0.736 0.769 0.702 0.768 0.772 0.749 0.793 0.700
View P35610 Sterol O-acyltransferase 1 0.656 0.688 0.684 0.582 0.793 0.724 0.735 0.718 0.633 0.837
View P35869 Aryl hydrocarbon receptor 0.638 0.684 0.670 0.578 0.762 0.615 0.644 0.639 0.558 0.725
View P36544 Neuronal acetylcholine receptor subunit alpha-7 0.735 0.761 0.741 0.715 0.768 0.793 0.837 0.788 0.801 0.774
View P37231 Peroxisome proliferator-activated receptor gamma 0.796 0.824 0.805 0.761 0.849 0.803 0.833 0.814 0.760 0.867
View P39900 Macrophage metalloelastase 0.790 0.839 0.812 0.708 0.917 0.777 0.836 0.791 0.687 0.909
View P41231 P2Y purinoceptor 2 0.870 0.871 0.869 0.876 0.861 0.862 0.860 0.853 0.909 0.796
View P42261 Glutamate receptor 1 0.750 0.767 0.761 0.724 0.797 0.759 0.767 0.767 0.733 0.800
View P42262 Glutamate receptor 2 0.670 0.781 0.737 0.526 0.955 0.722 0.773 0.821 0.591 0.971
View P42345 Serine/threonine-protein kinase mTOR 0.774 0.782 0.767 0.793 0.741 0.780 0.795 0.773 0.836 0.715
View P42574 Caspase-3 0.757 0.771 0.759 0.761 0.757 0.763 0.791 0.774 0.765 0.782
View P43681 Neuronal acetylcholine receptor subunit alpha-4 0.700 0.716 0.708 0.677 0.739 0.732 0.740 0.736 0.710 0.763
View P48039 Melatonin receptor type 1A 0.755 0.767 0.762 0.729 0.796 0.759 0.758 0.756 0.771 0.741
View P48147 Prolyl endopeptidase 0.762 0.769 0.753 0.790 0.716 0.826 0.831 0.817 0.864 0.769
View P49682 C-X-C chemokine receptor type 3 0.810 0.835 0.819 0.768 0.871 0.845 0.872 0.852 0.782 0.926
View P49768 Presenilin-1 0.844 0.859 0.853 0.785 0.922 0.914 0.921 0.923 0.842 1.000
View P49810 Presenilin-2 0.823 0.879 0.837 0.749 0.927 0.900 0.913 0.899 0.885 0.914
View P49840 Glycogen synthase kinase-3 alpha 0.772 0.834 0.812 0.631 0.996 0.750 0.815 0.805 0.600 1.000
View P49841 Glycogen synthase kinase-3 beta 0.717 0.713 0.698 0.762 0.632 0.750 0.762 0.736 0.804 0.670
View P49862 Kallikrein-7 0.348 0.609 0.722 0.357 0.818 0.250 0.571 0.735 0.300 0.810
View P50052 Type-2 angiotensin II receptor 0.885 0.894 0.888 0.860 0.917 0.886 0.921 0.891 0.881 0.901
View P50406 5-hydroxytryptamine receptor 6 0.761 0.829 0.777 0.706 0.848 0.762 0.838 0.778 0.708 0.849
View P51677 C-C chemokine receptor type 3 0.860 0.886 0.861 0.860 0.862 0.886 0.913 0.885 0.867 0.904
View P51681 C-C chemokine receptor type 5 0.883 0.898 0.886 0.867 0.905 0.886 0.896 0.884 0.862 0.908
View P52732 Kinesin-like protein KIF11 0.704 0.784 0.726 0.647 0.806 0.780 0.861 0.796 0.725 0.866
View P55055 Oxysterols receptor LXR-beta 0.878 0.895 0.883 0.836 0.931 0.938 0.955 0.946 1.000 0.909
View P55210 Caspase-7 0.764 0.814 0.800 0.678 0.911 0.768 0.789 0.792 0.674 0.915
View P55211 Caspase-9 0.552 0.620 0.599 0.556 0.633 0.574 0.585 0.581 0.600 0.565
View P55212 Caspase-6 0.543 0.584 0.567 0.610 0.536 0.625 0.654 0.633 0.789 0.533
View P56817 Beta-secretase 1 0.809 0.822 0.816 0.776 0.857 0.815 0.818 0.809 0.802 0.816
View P78536 Disintegrin and metalloproteinase domain-containing protein 17 0.856 0.878 0.858 0.849 0.866 0.842 0.888 0.849 0.812 0.886
View Q00535 Cyclin-dependent-like kinase 5 0.722 0.729 0.722 0.716 0.728 0.762 0.771 0.758 0.793 0.725
View Q01959 Sodium-dependent dopamine transporter 0.712 0.724 0.712 0.708 0.716 0.698 0.705 0.697 0.681 0.714
View Q02750 Dual specificity mitogen-activated protein kinase kinase 1 0.853 0.881 0.861 0.799 0.924 0.868 0.900 0.881 0.818 0.939
View Q03181 Peroxisome proliferator-activated receptor delta 0.811 0.848 0.823 0.763 0.882 0.803 0.860 0.827 0.757 0.888
View Q05586 Glutamate receptor ionotropic, NMDA 1 0.656 0.690 0.671 0.624 0.719 0.807 0.773 0.784 0.815 0.744
View Q07343 cAMP-specific 3',5'-cyclic phosphodiesterase 4B 0.757 0.754 0.745 0.782 0.708 0.756 0.763 0.763 0.753 0.772
View Q07869 Peroxisome proliferator-activated receptor alpha 0.841 0.872 0.852 0.786 0.917 0.853 0.882 0.855 0.802 0.914
View Q13224 Glutamate receptor ionotropic, NMDA 2B 0.655 0.673 0.672 0.618 0.728 0.582 0.582 0.574 0.561 0.588
View Q13526 Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 0.506 0.486 0.491 0.571 0.424 0.703 0.719 0.744 0.684 0.792
View Q13627 Dual specificity tyrosine-phosphorylation-regulated kinase 1A 0.773 0.815 0.776 0.754 0.799 0.770 0.795 0.769 0.770 0.767
View Q13936 Voltage-dependent L-type calcium channel subunit alpha-1C 0.824 0.832 0.831 0.803 0.857 0.828 0.838 0.839 0.800 0.875
View Q14289 Protein-tyrosine kinase 2-beta 0.871 0.886 0.865 0.907 0.823 0.851 0.897 0.857 1.000 0.759
View Q14790 Caspase-8 0.883 0.875 0.874 0.881 0.866 0.901 0.894 0.877 0.881 0.872
View Q15078 Cyclin-dependent kinase 5 activator 1 0.738 0.746 0.734 0.745 0.723 0.746 0.753 0.739 0.768 0.711
View Q15303 Receptor tyrosine-protein kinase erbB-4 0.859 0.877 0.870 0.780 0.963 0.941 0.950 0.951 0.941 0.958
View Q16572 Vesicular acetylcholine transporter 0.888 0.890 0.878 0.963 0.791 0.914 0.896 0.895 0.946 0.821
View Q16620 BDNF/NT-3 growth factors receptor 0.739 0.760 0.731 0.759 0.704 0.813 0.770 0.778 0.813 0.727
View Q16739 Ceramide glucosyltransferase 0.932 0.936 0.935 0.873 1.000 0.968 0.969 0.963 0.938 1.000
View Q5S007 Leucine-rich repeat serine/threonine-protein kinase 2 0.834 0.859 0.852 0.735 0.971 0.858 0.884 0.875 0.762 0.986
View Q8WW43 Gamma-secretase subunit APH-1B 0.828 0.870 0.840 0.767 0.913 0.921 0.912 0.914 0.935 0.889
View Q92731 Estrogen receptor beta 0.719 0.741 0.720 0.718 0.721 0.726 0.756 0.725 0.706 0.746
View Q96EB6 NAD-dependent protein deacetylase sirtuin-1 0.565 0.686 0.671 0.644 0.684 0.688 0.748 0.700 0.825 0.617
View Q99720 Sigma non-opioid intracellular receptor 1 0.686 0.716 0.707 0.640 0.775 0.698 0.729 0.714 0.638 0.796
View Q9NR96 Toll-like receptor 9 0.593 0.646 0.610 0.564 0.657 0.716 0.699 0.686 0.756 0.610
View Q9NZ42 Gamma-secretase subunit PEN-2 0.848 0.864 0.865 0.746 0.986 0.897 0.910 0.917 0.867 0.952
View Q9Y5Z0 Beta-secretase 2 0.839 0.847 0.833 0.866 0.799 0.865 0.861 0.850 0.964 0.736

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